En DNA-bindande, anonym kärnreceptor som negativt reglerar uttryck av ARNTL-transkriptionsfaktorer och som medverkar i regleringen av den biologiska klockan. Uttrycket av Nr1d1-kärnreceptorn regleras cykliskt genom en återkopplande loop med positiv reglering via klockprotein och ARNTL-transkriptionsfaktorheterodimerer, och negativ reglering via kryptokrom och dygnsperiodproteiner.
A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
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V-erbA-Related Protein EAR-1 — V erbA Related Protein EAR 1 — Nuclear Receptor NR1D1 — NR1D1, Nuclear Receptor — Receptor NR1D1, Nuclear — Rev-erb-alpha Nuclear Receptors — Nuclear Receptors, Rev-erb-alpha — Rev erb alpha Nuclear Receptors