NFATC Transcription Factors

NFATC-transkriptionsfaktorer

Svensk definition

En familj transkriptionsfaktorer vars kännetecken är närvaro av väl bevarade kalcineurin- och DNA-bindande domäner. NFAT-proteiner aktiveras i cytoplasman av det kalciumberoende fosfataset kalcineurin. De överför kalciumsignaler till cellkärnan, där de kan samverka med transkriptionsfaktor AP-1 eller NF-kappa B och påbörja genetisk transkription av gener som har med celldifferentiering och utveckling att göra. NFAT-proteiner stimulerar T-cellsaktivering genom att sätta igång snabbverkande gener, så som interleukin-2.

Engelsk definition

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

Svenska synonymer

Inga svenska synonymer finns.

Engelska synonymer

Transcription Factors, NFATC — Transcription Factor NF-AT — NF-AT, Transcription Factor — Transcription Factor NF AT — Nuclear Factor of Activated T-Cells, Cytoplasmic — Nuclear Factor of Activated T Cells, Cytoplasmic — NFAT Proteins — NFATC Proteins — Nuclear Factors of Activated T-Cells — Nuclear Factors of Activated T Cells — NF-AT Proteins — NF AT Proteins — NFAT Transcription Factor 4 — NFATC3 Transcription Factor — Factor, NFATC3 Transcription — Transcription Factor, NFATC3 — NFATx Protein — Nuclear Factor of Activated T-Cells, Cytoplasmic 3 Protein — Nuclear Factor of Activated T Cells, Cytoplasmic 3 Protein — NF-AT4 Protein — NF AT4 Protein — NFAT4 Protein — NFATC3 Protein — NFAT Transcription Factor 2 — NFAT-2 Protein — NFAT 2 Protein — Nuclear Factor of Activated T-Cells, Cytoplasmic 1 Protein — Nuclear Factor of Activated T Cells, Cytoplasmic 1 Protein — NFATC1 Protein — NFATC1 Transcription Factor — Factor, NFATC1 Transcription — Transcription Factor, NFATC1 — NF-ATc1 Protein — NF ATc1 Protein — NFAT2 Protein — NFAT Transcription Factor 3 — NFATC4 Transcription Factor — Transcription Factor, NFATC4 — NFAT3 Protein — NFATC4 Protein — Nuclear Factor of Activated T-Cells, Cytoplasmic 4 Protein — Nuclear Factor of Activated T Cells, Cytoplasmic 4 Protein — NF-AT3 Protein — NF AT3 Protein — NFAT Transcription Factor 5 — Nuclear Factor of Activated T-Cells 5 Protein — Nuclear Factor of Activated T Cells 5 Protein — OREBP Protein — Osmotic Response Element Binding Protein — NFATL1 Protein — Tonicity-Responsive Enhancer-Binding Protein — Tonicity Responsive Enhancer Binding Protein — NFAT5 Protein — NFATz Protein — TonEBP Protein — NFAT Transcription Factor 1 — NFATC2 Transcription Factor — Factor, NFATC2 Transcription — Transcription Factor, NFATC2 — NFAT1 Protein — NFATC2 Protein — Nuclear Factor of Activated T-Cells, Cytoplasmic 2 Protein — Nuclear Factor of Activated T Cells, Cytoplasmic 2 Protein — NFAT-1 Protein — NFAT 1 Protein