Ett enzym som katalyserar omvandlingen av fosfatidylinositol till fosfatidylinositol-3-fosfat. Detta är det första steget i biosyntesen av fosfatidylinositol-3,4-bifosfat och fosfatidylinositol-3,4,5- trifosfat. Denna pathway tros spela en kritisk roll vid DNA-reparation, V(D)J-rekombinering och cellcykelkontrollpunkter. EC 2.7.1.137.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
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Phosphatidylinositol 3 Kinases — PI3-Kinase — PI3 Kinase — Phosphatidylinositol-3-OH Kinase — Kinase, Phosphatidylinositol-3-OH — Phosphatidylinositol 3 OH Kinase — Phosphoinositide 3-Hydroxykinase — 3-Hydroxykinase, Phosphoinositide — Phosphoinositide 3 Hydroxykinase — PI-3K — PtdIns 3-Kinases — PtdIns 3 Kinases — PI-3 Kinase — Kinase, PI-3 — PtdIns 3-Kinase — PtdIns 3 Kinase — PI3 Kinases — Kinases, PI3 — Phosphoinositide 3 Kinases — Kinases, Phosphoinositide 3 — PI 3-Kinase — PI 3 Kinase