Sex Hormone-Binding Globulin

Könshormonbindande globulin

Svensk definition

Ett glykoprotein som migrerar som beta-globulin. Molekylvikten, 52 000 eller 95 000-115 000, antyder att den förekommer som dimer. Proteinet binder testosteron, dihydrotestosteron och östradiol i plasma. Könshormonbindande globulin har samma aminosyrasekvens som androgenbindande protein. De syntetiseras dock på olika platser och genomgår olika oligosackaridmodifikationer efter translation.

Engelsk definition

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Svenska synonymer

Sexualhormonbindande globulin SHBG

Engelska synonymer

Globulin, Sex Hormone-Binding Hormone-Binding Globulin, Sex Sex Hormone Binding Globulin Sex Steroid-Binding Protein Sex Steroid Binding Protein Steroid-Binding Protein, Sex Testosterone-Estradiol Binding Globulin Binding Globulin, Testosterone-Estradiol Globulin, Testosterone-Estradiol Binding Testosterone Estradiol Binding Globulin