Den näst sista för cytolys avgörande komponenten i komplementreaktionsföljden. Den är ett gammaglobulin med molekylvikt på 150 000 och sedimentationskoefficient på 8. C8 finns i spårmängd i serum och kan hämmas, liksom komplement 1, med katjonkelatkomplexbildare.
A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Inga svenska synonymer finns.
C8, Complement — Complement Component 8 — Component 8, Complement — C8 Complement — Complement, C8 — Complement 8 — Complement Component C8 beta — Complement Component C8 beta Chain — Complement Component C8 gamma — Complement Component C8 gamma Chain — Complement Component C8 alpha — Complement Component C8 alpha Chain