Ett enzym som katalyserar den reversibla omvandlingen mellan glukos-6-fosfat och fruktos-6-fosfat och utgör en del av de glykolytiska och glukoneogena förloppen. Brist på enzymet, en autosomalt recessiv egenskap, leder till glykogenes i levern och hemolytisk anemi. EC 5.3.1.9.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Neuroleukin — Autokrin motilitetsfaktor
Glucose 6 Phosphate Isomerase — Isomerase, Glucose-6-Phosphate — Phosphohexose Isomerase — Isomerase, Phosphohexose — Phosphoglucose Isomerase — Isomerase, Phosphoglucose — Glucosephosphate Isomerase — Isomerase, Glucosephosphate — Isomerase, Glucose 6 Phosphate — Autocrine Motility Factor — Factor, Autocrine Motility — Motility Factor, Autocrine — Tumor Autocrine Motility Factor — Tumor-Cell Autocrine Motility Factor — Tumor Cell Autocrine Motility Factor — Neuroleukin