DNA-topoisomeraser som katalyserar ATP-beroende klyvning av båda DNA-strängar, genomföring av de obrutna strängarna genom brottpunkten och återförening av de kluvna strängarna. Dessa enzymer relaxerar superhelixvindlingarna och frigör en duplex-DNA-knutring. EC 5.99.1.3.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
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DNA Topoisomerase II — Type II DNA Topoisomerase — DNA Type 2 Topoisomerase — DNA Topoisomerase (ATP-Hydrolysing) — Topoisomerase II — DNA Topoisomerase II alpha — TOP2A Protein — Topoisomerase II alpha — alpha, Topoisomerase II — DNA Topoisomerase II beta — TOP2B Protein — Topoisomerase II beta — beta, Topoisomerase II