Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Inga svenska synonymer finns.
PROTAC Proteolysis Targeting Chimera — PROTACs — Proteolysis Targeting Chimeras — Chimeras, Proteolysis Targeting — Targeting Chimeras, Proteolysis — IAP-Based PROTACs — IAP Based PROTACs — VHL-Based PROTACs — VHL Based PROTACs — MDM2 Protein-Based PROTACs — MDM2 Protein Based PROTACs — Phospho-Dependent PROTACs — Phospho Dependent PROTACs — PhosphoPROTACs — Cereblon-Based Small-Molecule Compounds — Cereblon Based Small Molecule Compounds